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Polynucleotides

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REJUVENATE YOUR SKIN WITH POLYNUCLEOTIDE TREATMENTS

For skin that has lost its youthful exuberance and bounce, polynucleotide injectable treatments are the perfect solution.

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What are polynucleotides?

Polynucleotide treatments, commonly referred to as salmon sperm facials, are the hottest topic of the aesthetic industry at the moment and with their rapid surge in popularity, it’s essential to understand what these restorative injectables are. But what are polynucleotides, and how can they help resolve your clients’ top concerns?

In the world of aesthetics, polynucleotides are known as the future of regenerative injectables and are hailed for their ability to rejuvenate and regenerate the skin. Although similar to skin boosters, polynucleotide injectables are separated and well-recognised for their complex structures and ability to rejuvenate the skin with natural-looking results. However, unlike skin boosters, injectable polynucleotides are also renowned for their wound-healing and bio-stimulating properties.

What do polynucleotides do?

Polynucleotide injectables employ filtered, ultra-purified, and sterilised fractions of DNA, which are capable of rejuvenating the skin. Predominantly derived from salmon or trout DNA, polynucleotides are designed to stimulate fibroblasts, promoting tissue repair, enhancing cell turnover, increasing elasticity, and stimulating collagen production. Additionally, they can soothe inflammation and restore the balance of melanocyte activity (skin pigmentation), resulting in a more even and refreshed skin tone without adding the volume associated with products like dermal fillers.

Also frequently known as PN or PDRN, polynucleotides are categorised as a regenerative treatment to revitalise the skin on a deeper level. These injectables provide DNA molecules that encourage the skin to repair itself and promote various immediate and long-term skin-boosting benefits. This exciting advancement in regenerative medicine focuses on restoring normal cellular function by repairing the skin at a deeper level.

Polynulceotide benefits

  • Promotes collagen and elastin production which enhance skin elasticity, firmness and overall texture

  • Reduce the appearance of fine lines and wrinkles

  • Brightens skin

  • Increases hydration levels of the skin to achieve a fresher and more youthful complexion

  • Alleviates redness and inflammation (Including roscea)

  • Brightens under eye dark circles

  • Reduces hollowness under the eye by firming and plumping skin

  • ​Stimulate hair growth and improve scalp health

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Polynucleotide results 

Gradual Improvements

Significant improvements from polynucleotide treatments usually become noticeable within a few weeks. This is when the polynucleotides begin to stimulate collagen and elastin production, leading to better skin elasticity and firmness. The skin’s overall appearance continues to improve as these structural proteins rebuild and strengthen the skin matrix.

Long-term Results

The full benefits of polynucleotide treatments typically manifest after two to three months. By this time, the skin should appear significantly rejuvenated, with reduced fine lines and wrinkles, improved texture, and enhanced hydration. The long-lasting effects of polynucleotides can be maintained for six to twelve months, depending on individual factors and the specific area treated.

Factors Influencing the Duration of Results

Several factors can influence how long the results of a polynucleotide treatment last. These include:

  1. Skin Type and Condition: The initial condition of your skin and its ability to respond to treatment can affect the duration of the results.

  2. Age: Younger skin may respond more quickly and maintain results longer compared to older skin.

  3. Lifestyle: Factors such as diet, hydration, sun exposure, and skincare routines can impact the longevity of the treatment’s effects.

  4. Treatment Area: Different areas of the skin may respond differently to treatment, influencing how long the results last.

Maintenance Treatments

To maintain the benefits of polynucleotide treatments, periodic maintenance sessions are recommended. These follow-up treatments help to sustain the improvements in skin texture, hydration, and elasticity. Your practitioner will advise on the optimal frequency for maintenance sessions based on your individual needs and the specific characteristics of your skin.

Frequently Asked Questions

1: What are Polynucleotides?
Polynucleotides are natural, biocompatible molecules derived from Salmon DNA. When injected into the skin they stimulate deep regeneration by:
- Boosting collagen and elastin production
- Improving skin texture and elasticity
- Enhancing hydration
- Reducing inflammation and oxidative stress


2: How are polynucleotides used?
Polynucleotide treatment involves multiple tiny injections into certain areas that we want to treat whether this is under the eyes, face, neck or scalp. 

3: What can they treat?
- Fine lines and wrinkles
- Dull, tired or dehydrated skin
- Under eye hollowing and dark circles
- Acne scars and general scarring
- Loss of skin elasticity
- Ageing or sun-damaged skin
- Hair thinning and scalp rejuenvation


4: How long do results last?
As for the results, you may start noticing subtle improvements as early as 1-2 weeks post-treatment such as hydration and glow. However, full regenerative benefits build over 3-6 weeks and continue improving with a course of treatments (usually 3 treatments, spaced 4 weeks apart. You will be able to enjoy the benefits of polynucleotides for up to 9 months, depending on skin condition, age, lifestyle and if the full course has been completed. For optimal and long-lasting resus, three treatments spread 4 weeks apart is recommended with one maintenance treatment per year is recommended at around 6/7 months.

5: Are there any risks to treatment?
Polynucleotides are generally considered a safe and well-tolerated treatment, with a low risk of adverse reactions. However, as with any injectable procedure, it’s essential to choose a qualified and experienced healthcare provider to administer the treatment. During the consultation process, we will review your medical history and discuss any potential contraindications or risks associated with the treatment. Individuals with certain conditions, such as allergies to hyaluronic acid, active skin infections, or bleeding disorders, may not be suitable candidates for polynucleotides. It’s also important to follow the recommended pre- and post-treatment care instructions provided to ensure optimal results and minimize the risk of any complications.

 

Rare complications

  • Risk of Infection: Improper injection techniques or unsanitary conditions can lead to infections, which occur when bacteria enter the skin during treatment. Symptoms may include redness, warmth, or pus formation at the injection site. Choosing a skilled professional and a reputable clinic significantly reduces this risk.

  • Allergic Reactions: While uncommon, some individuals may experience allergic responses such as severe itching, redness, or swelling. These reactions may stem from sensitivity to certain ingredients in the formulation. Immediate medical attention is crucial to manage symptoms effectively.

  • Nodule Formation: Hard lumps or granulomas can develop under the skin due to the body’s response to the injected material. These nodules may persist if left untreated, but early detection and professional intervention can prevent long-term complications.



6: What are the side effects?
As with all injectable treatments, there is a risk of redness at injection site, tenderness, swelling and bruising.  With polynucleotides, you will feel and see blebs (lumps) at injection sites which will disappear over a few days. However, these can take longer in some people.

 

  • Swelling and Redness: Temporary swelling and redness at the injection site are common, indicating the body’s natural response to the treatment. These typically subside within a day or two.

  • Bruising and Discomfort: The injection process may cause mild bruising and discomfort. These effects are temporary and can be minimized with proper aftercare, such as using a cold compress.

  • Itching and Tenderness: Some patients may experience itching or tenderness in the treated area. These sensations usually resolve within a few days as the skin adapts to the treatment.



7: Is there any downtime?
Polynucleotides generally have minimal to no down time, which is why they're such a popular treatment.  Apart from the side effects mentioned above.  You can go back to your normal activities immediately, however, we do advise the following aftercare:
- Avoid make up for 24 hours
- No intense exercise for 24 hours
- No excessive heat or steam for 48 hours

8: Does it hurt?
While some discomfort may occur during the injection process, many clients describe it as mild. To reduce discomfort, topical numbing cream is applied beforehand.

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